Ultrasonography as a predictor of embryo implantation after in vitro fertilization:: a controlled study

Objective: To investigate the predictive value of ultrasonographic parameters as prognostic indicators of implantation after IVF when measured on the day of embryo transfer. Design: Comparative, observational study. Setting: University teaching hospital. Patient(s): Two hundred eighty patients undergoing IVF. Intervention(s): Ovarian stimulation, IVF. Main Outcome Measure(s): Variables related to patients' clinical characteristics, treatment characteristics, ovarian response, ovum retrieval, outcome of IVF and ICSI, embryo transfer, ultrasonographic and Doppler endometrial measurements, and uterine blood flow that have been proposed as potential predictive factors of implantation. All transvaginal ultrasonographic assessments were performed on the day of embryo transfer. Result(s): Among 240 patients finally evaluable, 67 (group 1) became pregnant after IVF, and 173 (group 2) failed to conceive. The 111 nonpregnant patients who had the same embryo score per replacement (group 3) as did patients in group 1 were selected for comparison purposes. The only significant differences between groups 1 and 3 were the type A endometrium and the absence of a protodiastolic notch in the uterine arteries, both of which were more frequently found in group 1. However, a considerable overlap existed between conception and nonconception cycles regarding both variables. Conclusion(s): Ultrasonographic parameters as predictors of implantation in assisted reproduction have a limited value in the clinical setting. (C) 2003 by American Society for Reproductive Medicine.