Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters

被引：50

作者：

Barn, DR ^{[1
]}

Morphy, JR ^{[1
]}

Rees, DC ^{[1
]}

机构：

[1] ORGANON RES LABS LTD,DEPT MED CHEM,NEWHOUSE ML1 5SH,LANARK,SCOTLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 18期

关键词：

D O I：

10.1016/0040-4039(96)00498-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of resin-bound benzylic esters to amides under ambient conditions. The reactions were monitored in 'real-time' using C-13 gel phase NMR. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3213 / 3216

页数：4

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