Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum

被引：86

作者：

Kiss, T

Kiss, E

Garribba, E

Sakurai, H

机构：

[1] Univ Debrecen, Dept Inorgan & Analyt Chem, H-4010 Debrecen, Hungary

[2] Attila Jozsef Univ, Dept Inorgan & Analyt Chem, H-6701 Szeged, Hungary

[3] Univ Sassari, Dept Chem, I-07710 Sassari, Italy

[4] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashima Ku, Kyoto 607, Japan

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 80卷 / 1-2期

基金：

匈牙利科学研究基金会;

关键词：

insulin-mimetic VO(IV); VO(IV)-containing drugs; blood serum;

D O I：

10.1016/S0162-0134(00)00041-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)(2), VO(picolinate)(2) and VO(6-Me-picolinate)(2), in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：65 / 73

页数：9

共 41 条

[1] PHOSPHATE COMPLEXATION OF OXOVANADIUM(IV) - EVIDENCE OF BIDENTATE CHELATION OF ORTHOPHOSPHATE [J].