Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

被引：191

作者：

Murray, D

BenTal, N

Honig, B

McLaughlin, S

机构：

[1] SUNY STONY BROOK,DEPT PHYSIOL & BIOPHYS,STONY BROOK,NY 11794

[2] TEL AVIV UNIV,DEPT BIOCHEM,IL-69978 TEL AVIV,ISRAEL

[3] COLUMBIA UNIV,DEPT BIOCHEM & MOL BIOPHYS,NEW YORK,NY 10032

来源：

STRUCTURE | 1997年 / 5卷 / 08期

关键词：

D O I：

10.1016/S0969-2126(97)00251-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.

引用

页码：985 / 989

页数：5

共 45 条

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