Activity of daptomycin against multi-resistant Gram-positive bacteria including enterococci and Staphylococcus aureus resistant to linezolid

被引：36

作者：

Johnson, AP ^{[1
]}

Mushtaq, S ^{[1
]}

Warner, M ^{[1
]}

Livermore, DM ^{[1
]}

机构：

[1] Hlth Protect Agcy, Antibiot Resistance Monitoring & Reference Lab, Special & Reference Mircobiol Div, London NW9 5HT, England

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 24卷 / 04期

关键词：

daptomycin; susceptibility testing; staphylococci; enterococci; streptococci; coryneforms;

D O I：

10.1016/j.ijantimicag.2004.04.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, beta-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were less than or equal to 1 mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were less than or equal to2 and less than or equal to4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：315 / 319

页数：5

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