A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody Fc-γ chain chimeric receptor gene recognizing a human ovarian cancer antigen

被引：48

作者：

Wang, G ^{[1
]}

Chopra, RK ^{[1
]}

Royal, RE ^{[1
]}

Yang, JC ^{[1
]}

Rosenberg, SA ^{[1
]}

Hwu, P ^{[1
]}

机构：

[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 1998年 / 4卷 / 02期

关键词：

D O I：

10.1038/nm0298-168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to treat common cancers with immunotherapy, chimeric receptors have been developed that combine the tumor specificity of antibodies with T-cell effector functions. Previously, we demonstrated that T cells transduced with a chimeric receptor gene against human ovarian cancer were able to recognize ovarian cancer cells in vitro and in vivo. We now report that recipients of bone marrow cells transduced with these genes exhibited significant antitumor activity in vivo. Moreover, in vivo depletion of T cells in reconstituted mice did not affect antitumor activity, suggesting that other immune cells expressing the chimeric receptor gene may play an important role in tumor rejection.

引用

页码：168 / 172

页数：5

共 32 条

[1] COMBINATION OF INTERLEUKIN-3 AND INTERLEUKIN-6 PRESERVES STEM-CELL FUNCTION IN CULTURE AND ENHANCES RETROVIRUS-MEDIATED GENE-TRANSFER INTO HEMATOPOIETIC STEM-CELLS [J].