Carotid intima-media thickness in heavily pretreated HIV-infected patients

被引:56
作者
Chironi, G
Escaut, T
Gariepy, J
Cogny, A
Monsuez, TJ
Levenson, J
Simon, A
Vittecoq, D
机构
[1] Hop Broussais, Ctr Med Prevent Cardiovasc, F-75674 Paris 14, France
[2] Hop Broussais, CNRS, Unite UMR7131, F-75674 Paris 14, France
[3] Hop Paul Brousse, Serv Malad Infect & Trop, Villejuif, France
[4] Hop Europeen Georges Pompidou, Serv Biochim, Paris, France
关键词
antiretroviral therapy; carotid arteries; HIV; intima-media thickness; risk factors;
D O I
10.1097/00126334-200304150-00004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p < .05) but not different from control group 2 IMT values. Positive independent associations of IMT with the total-to-HDL cholesterol ratio and waist circumference existed for cases (p < .05) but not for controls. Case IMT did not correlate with parameters of HIV infection and antiretroviral treatment. This case-control study suggests that lipid disturbances, mainly hypo-HDLemia, may be involved in the early atherosclerotic process in HIV-infected patients.
引用
收藏
页码:490 / 493
页数:4
相关论文
共 19 条
[1]  
ASSMANN G, 1983, CLIN CHEM, V29, P2026
[2]   Common carotid intima-media thickness and risk of stroke and myocardial infarction - The Rotterdam Study [J].
Bots, ML ;
Hoes, AW ;
Koudstaal, PJ ;
Hofman, A ;
Grobbee, DE .
CIRCULATION, 1997, 96 (05) :1432-1437
[3]   Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance [J].
Carr, A ;
Samaras, K ;
Chisholm, DJ ;
Cooper, DA .
LANCET, 1998, 351 (9119) :1881-1883
[4]  
Castelli W P, 1992, Ann Epidemiol, V2, P23, DOI 10.1016/1047-2797(92)90033-M
[5]  
Castelli WP, 1998, AM J CARDIOL, V82, p60T
[6]   Chronic infections and coronary heart disease: is there a link? [J].
Danesh, J ;
Collins, R ;
Peto, R .
LANCET, 1997, 350 (9075) :430-436
[7]   CEREBRAL INFARCTIONS AND TRANSIENT NEUROLOGIC DEFICITS ASSOCIATED WITH ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
ENGSTROM, JW ;
LOWENSTEIN, DH ;
BREDESEN, DE .
AMERICAN JOURNAL OF MEDICINE, 1989, 86 (05) :528-532
[8]   Sex and topographic differences in associations between large-artery wall thickness and coronary risk profile in a French working cohort -: The AXA Study [J].
Gariepy, J ;
Salomon, J ;
Denarié, N ;
Laskri, F ;
Mégnien, JL ;
Levenson, J ;
Simon, A .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (04) :584-590
[9]   Experimental and clinical validation of arterial diameter waveform and intimal media thickness obtained from B-mode ultrasound image processing [J].
Graf, S ;
Gariepy, J ;
Massonneau, M ;
Armentano, RL ;
Mansour, S ;
Barra, JG ;
Simon, A ;
Levenson, J .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1999, 25 (09) :1353-1363
[10]   Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations - A statement for healthcare professionals from the American Heart Association and the American College of Cardiology [J].
Grundy, SM ;
Pasternak, R ;
Greenland, P ;
Smith, S ;
Fuster, V .
CIRCULATION, 1999, 100 (13) :1481-1492