A single type of progenitor cell maintains normal epidermis

被引：651

作者：

Clayton, Elizabeth

Doupe, David P.

Klein, Allon M.

Winton, Douglas J.

Simons, Benjamin D.

Jones, Philip H. ^{[1
]}

机构：

[1] Hutchison MRC Res Ctr, MRC Canc Cell Unit, Cambridge CB2 0XZ, England

[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

[3] Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England

来源：

NATURE | 2007年 / 446卷 / 7132期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nature05574

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division(1-3). By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.

引用

页码：185 / 189

页数：5

共 29 条

[1]

Stem cells of the skin epithelium [J].