CLIP proteases and Plasmodium melanization in Anopheles gambiae

被引：59

作者：

Barillas-Mury, Carolina ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA

来源：

TRENDS IN PARASITOLOGY | 2007年 / 23卷 / 07期

关键词：

D O I：

10.1016/j.pt.2007.05.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Melanization is a potent immune response mediated by phenoloxidase (PO). Multiple Clip-domain serine proteases (CLIP) regulate PO activation as part of a complex cascade of proteases that are cleaved sequentially. The role of several CLIP as key activators or suppressors of the melanization responses of Anopheles gambiae to Plasmodium berghei (murine malaria) has been established recently using a genome-wide reverse genetics approach. Important differences in regulation of PO activation between An. gambiae strains were also identified. This review summarizes these findings and discusses our current understanding of the An. gambiae melanization responses to Plasmodium.

引用

页码：297 / 299

页数：3

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