Tribological process induced conformational transformation of protein may change the friction of cartilage

被引：5

作者：

Chang, Chih-Hung

Fang, Hsu-Wei

Huang, Huei-Ting

Liu, Hsuan-Liang

Lee, Wei-Ming

Hsieh, Man-Ching

Chen, Chiang-San

机构：

[1] Far Eastern Mem Hosp, Dept Surg, Div Orthopaed, Taipei, Taiwan

[2] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Taipei 106, Taiwan

[3] Natl Taipei Univ Technol, Inst Biotechnol, Taipei 106, Taiwan

来源：

MATERIALS LETTERS | 2007年 / 61卷 / 16期

关键词：

partial joint arthroplasty; cartilage; friction; albumin; tribochemistry; UHMWPE;

D O I：

10.1016/j.matlet.2006.11.077

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：3381 / 3384

页数：4

共 15 条

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