CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival

被引:53
作者
Bagnasco, S. M. [1 ]
Tsai, W.
Rahman, M. H.
Kraus, E. S.
Barisoni, L.
Vega, R.
Racusen, L. C.
Haas, M.
Mohammed, B. S.
Zachary, A. A.
Montgomery, R. A.
机构
[1] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[3] NYU Med Ctr, Dept Pathol, New York, NY 10016 USA
关键词
acute rejection; B cells; CD20; renal biopsy; renal transplantation;
D O I
10.1111/j.1600-6143.2007.01885.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
We examined rejection outcome and graft survival in 58 adult patients with acute cellular rejection Banff type I (ARI) or II (ARII), within 1 year after transplantation, with or without CD20-positive infiltrates. Antibody-mediated rejection was not examined. Of the 74 allograft biopsies, performed from 1999 to 2001, 40 biopsies showed ARI and 34 biopsies showed ARII; 30% of all the biopsies showed CD20-positive clusters with more than 100 cells, 9% with more than 200 cells and 5% with more than 275 cells. Patients with B cell-rich (> 100 or > 200/HPF CD20-positive cells) and B cell-poor biopsies (< 50 CD20-positive cells/HPF) were compared. Serum creatinine and eGFR of B cell-rich (CD20 > 100/HPF) and B cell-poor were not significantly different at rejection, or at 1, 3, 6 and 12 months, and during additional 3 years follow-up after rejection, although higher creatinine at 1 year was noted in the > 200/HPF group. Graft survival was also not different between B cell-rich and B cell-poor groups (p = 0.8 for > 100/HPF, p = 0.9 for > 200/HPF CD20-positive cells). Our data do not support association of B cell-rich infiltrates in allograft biopsies and worse outcome in acute rejection type I or II, but do not exclude the possible contribution of B cells to allograft rejection.
引用
收藏
页码:1968 / 1973
页数:6
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