Microscopic papillary thyroid carcinoma compared with clinical carcinomas by loss of heterozygosity mutational profile

被引:25
作者
Hunt, JL [1 ]
LiVolsi, VA [1 ]
Baloch, ZW [1 ]
Barnes, EL [1 ]
Swalsky, PA [1 ]
Niehouse, L [1 ]
Finkelstein, SD [1 ]
机构
[1] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
关键词
microcarcinoma; papillary carcinoma; thyroid; loss of heterozygosity; tumor suppressor gene;
D O I
10.1097/00000478-200302000-00003
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The clinical significance of microscopic papillary thyroid carcinoma (PTCa) is controversial. Many authors think that microscopic PTCa (<1 cm) have the same pathogenetic origin as clinically sized papillary carcinomas (>1 cm). Despite the fact that all clinical risk prognostication schemes have the size of the tumor as a primary category, small tumors do have malignant potential and can metastasize. There is growing evidence that small PTCa have the molecular translocations between the proto-oncogene RET and various activating partner genes that are characteristic of clinically sized PTCa. This study used a microdissection and genotyping assay to study the patterns of loss of heterozygosity of tumor suppressor genes in microscopic and clinically sized PTCa. Our results indicate that all PTCa harbor mutations with similar frequencies and distribution patterns, regardless of the size of the tumor. These data are further evidence that microscopic and clinically sized PTCa are pathogenetically related.
引用
收藏
页码:159 / 166
页数:8
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