Continuous growth of mean tumor diameter in a subset of grade II gliomas

被引：340

作者：

Mandonnet, E

Delattre, JY

Tanguy, ML

Swanson, KR

Carpentier, AF

Duffau, H

Cornu, P

Van Effenterre, R

Alvord, EC

Capelle, L

机构：

[1] Hop Salpetriere APHP, Federat Neurol Mazarin, Paris, France

[2] Hop Salpetriere APHP, INSERM, U495, Paris, France

[3] Hop Paul Brousse, INSERM, U472, Villejuif, France

[4] Univ Washington, Neuropathol Lab, Seattle, WA 98195 USA

[5] Hop La Pitie Salpetriere, Serv Neurochirurg, Paris, France

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 04期

关键词：

D O I：

10.1002/ana.10528

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1 mm per year (95% confidence interval, 3.8-4.4 mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.

引用

页码：524 / 528

页数：5

共 13 条

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