Microbial degradation of cyanobacterial cyclic peptides

被引：61

作者：

Kato, Hajime

Imanishi, Susumu Y.

Tsuji, Kiyomi

Harada, Ken-ichi

机构：

[1] Meijo Univ, Grad Sch Environm & Human Sci, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[2] Kanagawa Prefectural Inst Publ Hlth, Chigasaki, Kanagawa 2530087, Japan

[3] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

来源：

WATER RESEARCH | 2007年 / 41卷 / 08期

关键词：

microcystin; cyclic peptide; hydrolytic enzyme; biodegradation; Sphingomonas sp;

D O I：

10.1016/j.watres.2007.01.003

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bacterial strain B-9 possesses hydrolytic enzymes capable of degrading microcystins (MCs) and nodularin that are toxic cyclic peptides produced by cyanobacteria. In the present study, the degradation activities of the cell extract of B-9 against non-toxic cyanobacterial cyclic peptides other than the MCs and nodularin were investigated, and the degradation products were analyzed by liquid chromatography/ion trap tandem mass spectrometry (LC/ITMS). It was confirmed that B-9 could also degrade these cyanobacterial cyclic peptides by hydrolysis of their peptide bonds. These results indicated that this bacterium possesses a very unique hydrolytic activity that can degrade structurally different cyclic peptides and that this may be effective for the detoxification of hazardous cyclic peptides. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：1754 / 1762

页数：9

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