Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

被引：161

作者：

Wickline, Samuel A.

Neubauer, Anne M.

Winter, Patrick M.

Caruthers, Shelton D.

Lanza, Gregory M.

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

[3] Philips Med Syst, Best, Netherlands

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2007年 / 25卷 / 04期

关键词：

nanotechnology; contrast agents; imaging; drug therapy; atherosclerosis;

D O I：

10.1002/jmri.20866

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.

引用

收藏

页码：667 / 680

页数：14

相关论文

共 115 条

[1] In vivo imaging platform for tracking immunotherapeutic cells [J].

Ahrens, ET ;

Flores, R ;

Xu, HY ;

Morel, PA .

NATURE BIOTECHNOLOGY, 2005, 23 (08) :983-987

[2] A model for MRI contrast enhancement using T1 agents [J].

Ahrens, ET ;

Rothbächer, U ;

Jacobs, RE ;

Fraser, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8443-8448

[3] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[4] Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents [J].

Allen, M ;

Bulte, JWM ;

Liepold, L ;

Basu, G ;

Zywicke, HA ;

Frank, JA ;

Young, M ;

Douglas, T .

MAGNETIC RESONANCE IN MEDICINE, 2005, 54 (04) :807-812

[5]

Anderson SA, 2000, MAGNET RESON MED, V44, P433, DOI 10.1002/1522-2594(200009)44:3<433::AID-MRM14>3.0.CO

[6]

2-9

[7] Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic reisonance imaging after cell transplantation: Methods and techniques [J].

Arbab, AS ;

Bashaw, LA ;

Miller, BR ;

Jordan, EK ;

Bulte, JWM ;

Frank, JA .

TRANSPLANTATION, 2003, 76 (07) :1123-1130

[8] Near-infrared optical sensors based on single-walled carbon nanotubes [J].

Barone, PW ;

Baik, S ;

Heller, DA ;

Strano, MS .

NATURE MATERIALS, 2005, 4 (01) :86-U16

[9] Selective αvβ3-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit [J].

Bishop, GG ;

McPherson, JA ;

Sanders, JM ;

Hesselbacher, SE ;

Feldman, MJ ;

McNamara, CA ;

Gimple, LW ;

Powers, ER ;

Mousa, SA ;

Sarembock, IJ .

CIRCULATION, 2001, 103 (14) :1906-1911

[10]

Blankenberg Francis G., 2001, Cardiology Clinics, V19, P165, DOI 10.1016/S0733-8651(05)70202-2

← 1 2 3 4 5 6 7 8 9 10 →