Chiral Triphenylprolinol Ligands for the Efficient Catalytic Asymmetric Arylation of Aldehydes

被引：31

作者：

Moro, Angelica Venturini ^{[2
]}

Tiekink, Edward R. T. ^{[3
]}

Zukerman-Schpector, Julio ^{[4
]}

Luedtke, Diogo S. ^{[1
]}

Correia, Carlos Roque D. ^{[2
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo, Brazil

[2] Univ Estadual Campinas, Inst Quim, BR-13084917 Campinas, SP, Brazil

[3] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[4] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP, Brazil

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 19期

基金：

巴西圣保罗研究基金会;

关键词：

Asymmetric synthesis; Amino alcohols; Heck reaction; Chirality; Aldehydes; ARYL TRANSFER-REACTIONS; HIGHLY ENANTIOSELECTIVE ADDITION; ORGANOZINC REAGENTS; HECK ARYLATION; BORONIC ACIDS; ARENEDIAZONIUM SALTS; DIAZONIUM SALTS; TERTIARY ALCOHOLS; METHYL-ESTER; DERIVATIVES;

D O I：

10.1002/ejoc.201000336

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new chiral amino alcohols by Heck arylation of an enecarbamate is described. These compounds were used as chiral ligands for the catalytic asymmetric arylation of aldehydes and can be easily recovered. Chiral, nonracemic diarylmethanols were obtained in high yields and enantioselectivities.

引用

页码：3696 / 3703

页数：8

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