Enteric-coated layered double hydroxides as a controlled release drug delivery system

被引：120

作者：

Li, BX ^{[1
]}

He, J ^{[1
]}

Evans, DG ^{[1
]}

Duan, X ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Minist Educ, Key Lab Sci & Technol Controllable Chem React, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 287卷 / 1-2期

关键词：

layered double hydroxide; drug delivery system; coated;

D O I：

10.1016/j.ijpharm.2004.08.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Layered double hydroxides (LDHs) or so-called anionic clays consist of cationic brucite-like layers and exchangeable interlayer anions. Because of their biocompatibility, these layered inorganic solids can be used as host materials to create drug-LDH host-guest supramolecular structures. Because of the basicity of LDHs however, LDHs as drug delivery system will be limited for use in the stomach where pH is 1.2. A core-shell material has been prepared therefore in this work. A non-steroidal anti-inflammatory drug, Fenbufen-intercalated LDHs as the core was coated with enteric polymers, Eudragit(R) S 100 or Eudragit(R) L 100 as a shell, giving a composite material which shows controlled release of the drug under in vitro conditions which model the passage of a material through the gastrointestinal tract. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：89 / 95

页数：7

共 18 条

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