Dendritic cells and skin sensitization: Biological roles and uses in hazard identification

被引：50

作者：

Ryan, Cindy A.

Kimber, Ian

Basketter, David A.

Pallardy, Marc

Gildea, Lucy A.

Gerberick, G. Frank ^{[1
]}

机构：

[1] Procter & Gamble Co, Miami Valley Innovat Ctr, Cincinnati, OH 45253 USA

[2] Unilever Safety & Environm Assurance Ctr, Sharnbrook, Beds, England

[3] Univ Paris Sud, INSERM, UMR S 749, F-92296 Chatenay Malabry, France

[4] Syngenta Cent Toxicol Lab, Macclesfield, Cheshire, England

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2007年 / 221卷 / 03期

关键词：

skin sensitization; dendritic cells; in vitro methods; hazard identification;

D O I：

10.1016/j.taap.2007.03.006

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development of cellular assays (using DC and DC-like cells) for skin sensitization hazard identification. These alternative approaches to the identification and characterization of skin sensitizing chemicals were the focus of a Workshop entitled "Dendritic Cells and Skin Sensitization: Biological Roles and Uses in Hazard Identification" that was given at the annual Society of Toxicology meeting held March 6-9, 2006 in San Diego, California. This paper reports information that was presented during the Workshop. (c) 2007 Published by Elsevier Inc.

引用

收藏

页码：384 / 394

页数：11

相关论文

共 115 条

[1]

p38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene [J].

Aiba, S ;

Manome, H ;

Nakagawa, S ;

Mollah, ZUA ;

Mizuashi, M ;

Ohtani, T ;

Yoshino, Y ;

Tagami, H .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (03) :390-399

[2]

Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules [J].

Aiba, S ;

Terunuma, A ;

Manome, H ;

Tagami, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (11) :3031-3038

[3]

In vitro treatment of human transforming growth factor-β1-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction [J].

Aiba, S ;

Manome, H ;

Yoshino, Y ;

Tagami, H .

IMMUNOLOGY, 2000, 101 (01) :68-75

[4]

Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation [J].

Angelini, G ;

Gardella, S ;

Ardy, M ;

Ciriolo, MR ;

Filomeni, G ;

Di Trapani, G ;

Clarke, F ;

Sitia, R ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1491-1496

[5]

The cellular pathway of CD1e in immature and maturing dendritic cells [J].

Angénieux, C ;

Fraisier, V ;

Maître, B ;

Racine, V ;

van der Wel, N ;

Fricker, D ;

Proamer, F ;

Sachse, M ;

Cazenave, JP ;

Peters, P ;

Goud, B ;

Hanau, D ;

Sibarita, JB ;

Salamero, J ;

de la Salle, H .

TRAFFIC, 2005, 6 (04) :286-302

[6]

Functional caspase-1 is required for langerhans cell migration and optimal contact sensitization in mice [J].

Antonopoulos, H ;

Cumberbatch, M ;

Dearman, RJ ;

Daniel, RJ ;

Kimber, I ;

Groves, RW .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3672-3677

[7]

Skin sensitization: Reaction mechanistic applicability domains for structure-activity relationships [J].

Aptula, AO ;

Patlewicz, G ;

Roberts, DW .

CHEMICAL RESEARCH IN TOXICOLOGY, 2005, 18 (09) :1420-1426

[8]

The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells [J].

Ardeshna, KM ;

Pizzey, AR ;

Devereaux, S ;

Khwaja, A .

BLOOD, 2000, 96 (03) :1039-1046

[9]

A critical pole for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers [J].

Arrighi, JF ;

Rebsamen, M ;

Rousset, F ;

Kindler, V ;

Hauser, C .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3837-3845

[10]

Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT) I. Optimization of the h-CLAT protocol [J].

Ashikaga, T ;

Yoshida, Y ;

Hirota, M ;

Yoneyama, K ;

Itagaki, H ;

Sakaguchi, H ;

Miyazawa, M ;

Ito, Y ;

Suzuki, H ;

Toyoda, H .

TOXICOLOGY IN VITRO, 2006, 20 (05) :767-773

← 1 2 3 4 5 6 7 8 9 10 →