Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation

被引：203

作者：

Morant, M

Bak, S

Moller, BL

Werck-Reichhart, D

机构：

[1] Univ Strasbourg, Inst Plant Mol Biol, Dept Plant Stress Response, CNRS,UPR2357, F-67000 Strasbourg, France

[2] Royal Vet & Agr Univ, Plant Biochem Lab, Dept Plant Biol, DK-1871 Frederiksberg C, Copenhagen, Denmark

[3] Royal Vet & Agr Univ, Ctr Mol Plant Physiol, PlaCe, DK-1871 Frederiksberg C, Copenhagen, Denmark

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(03)00024-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochromes P450 catalyse extremely diverse and often complex regiospecific and/or stereospecific reactions in the biosynthesis or catabolism of plant bioactive molecules. Engineered P450 expression is needed for low-cost production of antineoplastic drugs such as taxol or indole alkaloids and offers the possibility to increase the content of nutraceuticals such as phytoestrogens and antioxidants in plants. Natural products may serve important functions in plant defence and metabolic engineering of P450s is a prime target to improve plant defence against insects and pathogens. Herbicides, pollutants and other xenobiotics are metabolised by some plant P450 enzymes. These P450s are tools to modify herbicide tolerance, as selectable markers and for bioremediation.

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页码：151 / 162

页数：12

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