Cytosporone E: racemic synthesis and preliminary antibacterial testing

被引：35

作者：

Hall, JD

Duncan-Gould, NW

Siddiqi, NA

Kelly, JN

Hoeferlin, LA

Morrison, SJ

Wyatt, JK

机构：

[1] Coll Charleston, Dept Chem & Biochem, Charleston, SC 29424 USA

[2] Coll Charleston, Dept Biol, Charleston, SC 29424 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 04期

关键词：

phthalide; antibiotic; Meyers ortho-alkylation; chiral oxazoline; endophytic fungus;

D O I：

10.1016/j.bmc.2004.10.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1409 / 1413

页数：5

共 13 条

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