Syndecan captures, protects, and transmits HIV to T lymphocytes

被引:175
作者
Bobardt, MD
Saphire, ACS
Hung, HC
Yu, XC
Van der Schueren, B
Zhang, Z
David, G
Gallay, PA
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[2] Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium
[3] Flanders Interuniv Inst Biotechnol, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S1074-7613(02)00504-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study demonstrates that syndecan functions as an in trans HIV receptor. We show that syndecan, when expressed in nonpermissive cells, becomes the major mediator for HIV adsorption. This adsorption is mediated by the binding of gp120 to the heparan sulfate chains of syndecan. Although syndecan does not substitute for HIV entry receptors, it enhances the in trans infectivity of a broad range of primate lentiviruses including primary viruses produced from PBMCs. Furthermore, syndecan preserves virus infectivity for a week, whereas unbound virus loses its infectivity in less than a day. Moreover, we obtain evidence suggesting that the vast syndecan-rich endothelial lining of the vasculature can provide a microenvironment which boosts HIV replication in T cells.
引用
收藏
页码:27 / 39
页数:13
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