Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis

被引：68

作者：

Bettencourt, MV ^{[1
]}

Bosne-David, S ^{[1
]}

Amaral, L ^{[1
]}

机构：

[1] Univ Nova Lisboa, Inst Hyg & Trop Med, Mycobacteriol Unit, P-1349008 Lisbon, Portugal

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 16卷 / 01期

关键词：

in vitro activity; phenothiazines; multidrug-resistant; Mycobacterium tuberculosis;

D O I：

10.1016/S0924-8579(00)00199-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The comparative activity of five phenothiazines against multidrug-resistant strains of Mycobacterium tuberculosis (MDRTB) was studied using the Bactec 460 system. The order of antimycobacterial activity of the phenothiazines was: chlorpromazine = thioridazine > promethazine > promazine = desipramine. However, the levels required for an MIC 50 exceeded 1 mg/l and are beyond those that are clinically achievable. As phenothiazines are concentrated by macrophages that phagocytose and have in situ activity against mycobacteria, these agents may be considered for use as adjuvants for the management of freshly diagnosed tuberculosis in patients from populations with a high prevalence of MDRTB. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：69 / 71

页数：3

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