Effect of glutamate transporter on neuronal damage induced by photochemical thrombotic brain ischemia

被引：21

作者：

Yan, YP

Yin, KJ

Sun, FY ^{[1
]}

机构：

[1] Shanghai Med Univ, Natl Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[2] Shanghai Med Univ, Dept Neurobiol, Shanghai 200032, Peoples R China

来源：

NEUROREPORT | 1998年 / 9卷 / 03期

关键词：

cerebral ischemia; glutamate transporter; glutamate uptake inhibitor; neurotoxicity;

D O I：

10.1097/00001756-199802160-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To study the effects of glutamate transporters on the pathogenesis of brain infarct, pharmacological and histological analyses were carried out on the thrombotic focal ischemic model. Expression of mRNA coding for the glutamate transporter GLAST increased significantly in the penumbra at 72 h following the ischemia. Combined with confocal laser scanning microscopic analysis, double staining showed expression of GLAST mRNA in both neurons and glial cells in the penumbra. L-trans-Pyrrolidine-2,4-dicarboxylate (L-trans-PDC), a glutamate uptake inhibitor, dose-dependently enhanced the volume of the infarct induced by the ischemia. The results suggest that a compensatory increase in the activity of glutamate transporter may accompany pathogical changes after ischemic injury. (C) 1998 Rapid Science Ltd.

引用

页码：441 / 446

页数：6

共 25 条

[1] NA+-DEPENDENT HIGH-AFFINITY UPTAKE OF L-GLUTAMATE IN CULTURED FIBROBLASTS [J].