Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry

被引：34

作者：

Stewart, KD

Loren, S

Frey, L

Otis, E

Klinghofer, V

Hulkower, KI

机构：

[1] Abbott Labs, Dept Adv Technolga, Abbott Pk, IL 60064 USA

[2] Abbott Labs, Dept Immunol Dis Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00068-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using a combination of computational and combinatorial chemistry methodologies, a phenothiazine compound was discovered that is a selective inhibitor of cyclooxygenase-2 and serves as a lead compound for a potentially novel series of anti-inflammatory compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：529 / 534

页数：6

共 9 条

[1] USING SHAPE COMPLEMENTARITY AS AN INITIAL SCREEN IN DESIGNING LIGANDS FOR A RECEPTOR-BINDING SITE OF KNOWN 3-DIMENSIONAL STRUCTURE [J].