AIRE expands: new roles in immune tolerance and beyond

被引：175

作者：

Anderson, Mark S. ^{[1
]}

Su, Maureen A. ^{[2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[2] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 04期

关键词：

THYMIC EPITHELIAL-CELLS; REGULATORY T-CELLS; PROMISCUOUS GENE-EXPRESSION; TISSUE-RESTRICTED ANTIGENS; AUTOIMMUNE REGULATOR; SELF-ANTIGEN; IMMUNOLOGICAL-TOLERANCE; P-TEFB; DIFFERENTIATION PROGRAM; ECTOPIC EXPRESSION;

D O I：

10.1038/nri.2016.9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this transcription factor has a crucial role in promoting self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery. In this Review, we highlight many of the recent advances in our understanding of the complex biology that is related to AIRE, with a particular focus on advances in genetics, molecular interactions and the effect of AIRE on thymic selection of regulatory T cells. Furthermore, we highlight new areas of biology that are potentially affected by this key regulator of immune tolerance.

引用

页码：247 / 258

页数：12

共 92 条

[1]

Aire's Partners in the Molecular Control of Immunological Tolerance [J].

Abramson, Jakub ;

Giraud, Matthieu ;

Benoist, Christophe ;

Mathis, Diane .

CELL, 2010, 140 (01) :123-135

[2]

Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation [J].

Akiyama, Nobuko ;

Shinzawa, Miho ;

Miyauchi, Maki ;

Yanai, Hiromi ;

Tateishi, Ryosuke ;

Shimo, Yusuke ;

Ohshima, Daisuke ;

Matsuo, Koichi ;

Sasaki, Izumi ;

Hoshino, Katsuaki ;

Wu, Guoying ;

Yagi, Shintaro ;

Inoue, Jun-ichiro ;

Kaisho, Tsuneyasu ;

Akiyama, Taishin .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (12) :2425-2438

[3]

The cellular mechanism of Aire control of T cell tolerance [J].

Anderson, MS ;

Venanzi, ES ;

Chen, ZB ;

Berzins, SP ;

Benoist, C ;

Mathis, D .

IMMUNITY, 2005, 23 (02) :227-239

[4]

Projection of an immunological self shadow within the thymus by the aire protein [J].

Anderson, MS ;

Venanzi, ES ;

Klein, L ;

Chen, ZB ;

Berzins, SP ;

Turley, SJ ;

von Boehmer, H ;

Bronson, R ;

Dierich, A ;

Benoist, C ;

Mathis, D .

SCIENCE, 2002, 298 (5597) :1395-1401

[5]

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells [J].

Aschenbrenner, Katharina ;

D'Cruz, Louise M. ;

Vollmann, Elisabeth H. ;

Hinterberger, Maria ;

Emmerich, Jan ;

Swee, Lee Kim ;

Rolink, Antonius ;

Klein, Ludger .

NATURE IMMUNOLOGY, 2007, 8 (04) :351-358

[6]

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[7]

On your histone mark, SET, methylate! [J].

Binda, Olivier .

EPIGENETICS, 2013, 8 (05) :457-463

[8]

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells [J].

Brennecke, Philip ;

Reyes, Alejandro ;

Pinto, Sheena ;

Rattay, Kristin ;

Nguyen, Michelle ;

Kuechlert, Rita ;

Huber, Wolfgang ;

Kyewski, Bruno ;

Steinmetz, Lars M. .

NATURE IMMUNOLOGY, 2015, 16 (09) :933-941

[9]

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

[10]

A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis [J].

Cetani, F ;

Barbesino, G ;

Borsari, S ;

Pardi, E ;

Cianferotti, L ;

Pinchera, A ;

Marcocci, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4747-4752

← 1 2 3 4 5 6 7 8 9 10 →