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Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease
被引：30
作者：
Brighina, Laura
[1
]
Prigione, Alessandro
[1
]
Begni, Barbara
[1
,2
]
Galbussera, Alessio
[1
]
Andreoni, Simona
[1
]
Piolti, Roberto
[1
]
Ferrarese, Carlo
[1
,2
]
机构：
[1] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, Neurobiol Lab, San Gerardo Hosp, Monza, Italy
[2] Sci Inst E Medea, Bosisio Parini, Lecco, Italy
关键词：
Alpha-synuclein;
Parkinson disease;
Lymphomonocytes;
Age;
Gender;
Proteasome;
D O I：
10.1016/j.neurobiolaging.2008.06.010
中图分类号：
R592 [老年病学];
C [社会科学总论];
学科分类号：
03 ;
0303 ;
100203 ;
摘要：
In this study we employed an ELISA assay to measure alpha-synuclein protein in lymphomonocytes from 78 PD patients and 78 controls. We correlated protein levels with demographic and clinical characteristics and with the chymotryptic and tryptic activities of the 20S proteasome. Alpha-synuclein levels were not significantly different between patients and controls. In control subjects, alpha-synuclein protein levels increased significantly with age and were significantly higher in men compared to women. Proteasome activity was not significantly different between cases and controls. In control group, the 20S chymotryptic activity tended to decrease significantly with increasing age, though it was not correlated to alpha-synuclein levels. The 20S tryptic activity was not significantly correlated to age, but was inversely correlated to alpha-synuclein levels. Our findings suggest that alpha-synuclein levels in lymphomonocytes are affected by age, gender, and by the 20S proteasome activity in control subjects, but they are not useful as a diagnostic biomarker for PD. (C) 2008 Elsevier Inc. All rights reserved.
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页码：884 / 885
页数：2
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