A Madagascar sponge Batzella sp as a source of alkylated iminosugars

被引：40

作者：

Segraves, NL

Crews, P ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 01期

关键词：

D O I：

10.1021/np049763g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new C-alkylated iminosugars, batzellasides A (3), B (4), and C (5), along with the known halitoxin (2) polymer were isolated from a Batzella sp. sponge, collected off the west coast of Madagascar. Although this class of azasugars is well known from terrestrial sources, our report represents the first examples of iminosugars from a marine organism. Comparison with the properties of known natural and synthetic iminosugars assisted in the structure determinations. Compounds 3-5 inhibited the growth of Staphylococcus epidermidis with MICs of less than or equal to6.3 mug/mL.

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页码：118 / 121

页数：4

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