Reciprocal regulation of polarized cytokine production by effector B and T cells

被引：640

作者：

Harris, DP ^{[1
]}

Haynes, L ^{[1
]}

Sayles, PC ^{[1
]}

Duso, DK ^{[1
]}

Eaton, SM ^{[1
]}

Lepak, NM ^{[1
]}

Johnson, LL ^{[1
]}

Swain, SL ^{[1
]}

Lund, FE ^{[1
]}

机构：

[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 06期

关键词：

D O I：

10.1038/82717

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although B cells produce cytokines it is not known whether B cells can differentiate into effector subsets that secrete polarized arrays of cytokines. We have identified two populations of "effector" B cells (Bel and Be2) that produce distinct patterns of cytokines depending on the cytokine environment in which the cells were stimulated during their primary encounter with antigen and T cells. These effector B cell subsets subsequently regulate the differentiation of naive CD4(+)T cells to T(H)1 and T(H)2 cells through production of polarizing cytokines such as interleukin 4 and interferon gamma. In addition, Eel and Be2 cells could, be identified in animals that were infected with pathogens that preferentially induce a Type I or Type 2 immune response. Together these results suggest that, in addition to their well defined role in antibody production, B cells may regulate immune responses to infectious pathogens through their production of cytokines.

引用

页码：475 / 482

页数：8

共 46 条

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