Negative regulation of TCR signaling and T-cell activation by selective protein degradation

被引：38

作者：

Jang, IK ^{[1
]}

Gu, H ^{[1
]}

机构：

[1] NIAID, Immunol Lab, Rockville, MD 20852 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(03)00048-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently control the duration and specificity of TCR signaling.

引用

收藏

页码：315 / 320

页数：6

相关论文

共 36 条

[1] Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking [J].

Babst, M ;

Odorizzi, G ;

Estepa, EJ ;

Emr, SD .

TRAFFIC, 2000, 1 (03) :248-258

[2] Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [J].

Bachmaier, K ;

Krawczyk, C ;

Kozieradzki, I ;

Kong, YY ;

Sasaki, T ;

Oliveira-dos-Santos, A ;

Mariathasan, S ;

Bouchard, D ;

Wakeham, A ;

Itie, A ;

Le, J ;

Ohashi, PS ;

Sarosi, I ;

Nishina, H ;

Lipkowitz, S ;

Penninger, JM .

NATURE, 2000, 403 (6766) :211-216

[3] Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist partial agonist properties and strictly correlates with T cell activation [J].

Bachmann, MF ;

Oxenius, A ;

Speiser, DE ;

Mariathasan, S ;

Hengartner, H ;

Zinkernagel, RM ;

Ohashi, PS .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (09) :2195-2203

[4] Cbl-b regulates the CD28 dependence of T-cell activation [J].

Chiang, YPJ ;

Kole, HK ;

Brown, K ;

Naramura, M ;

Fukuhara, S ;

Hu, RJ ;

Jang, IK ;

Gutkind, JS ;

Shevach, E ;

Gu, H .

NATURE, 2000, 403 (6766) :216-220

[5] Dysregulation of T lymphocyte function in itchy mice:: a role for itch in TH2 differentiation [J].

Fang, DY ;

Elly, C ;

Gao, BX ;

Fang, N ;

Altman, Y ;

Joazeiro, C ;

Hunter, T ;

Copeland, N ;

Jenkins, N ;

Liu, YC .

NATURE IMMUNOLOGY, 2002, 3 (03) :281-287

[6] Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells [J].

Fang, DY ;

Liu, YC .

NATURE IMMUNOLOGY, 2001, 2 (09) :870-875

[7] The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl [J].

Hawash, IY ;

Kesavan, KP ;

Magee, AI ;

Geahlen, RL ;

Harrison, ML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) :5683-5691

[8] Protein regulation by monoubiquitin [J].

Hicke, L .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (03) :195-201

[9] Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling [J].

Holland, SJ ;

Liao, XC ;

Mendenhall, MK ;

Zhou, XL ;

Pardo, J ;

Chu, P ;

Spencer, C ;

Fu, A ;

Sheng, N ;

Yu, PW ;

Pali, E ;

Nagin, A ;

Shen, M ;

Yu, S ;

Chan, E ;

Wu, X ;

Li, C ;

Woisetschlager, M ;

Aversa, G ;

Kolbinger, F ;

Bennett, MK ;

Molineaux, S ;

Luo, Y ;

Payan, DG ;

Mancebo, HSY ;

Wu, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (09) :1263-1276

[10]

Itoh Y, 1999, J IMMUNOL, V162, P2073

← 1 2 3 4 →