The role of mitochondria in cellular defense against microbial infection

被引：87

作者：

Arnoult, Damien ^{[1
]}

Carneiro, Leticia ^{[2
]}

Tattoli, Ivan ^{[2
]}

Girardin, Stephen E. ^{[2
]}

机构：

[1] Hop Paul Brousse, INSERM, U542, F-94807 Villejuif, France

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 04期

基金：

加拿大健康研究院;

关键词：

Mitochondria; Innate immunity; Viruses; Bacteria; Microbial pathogenesis; RIG-I; MAVS; NLRX1; DOUBLE-STRANDED-RNA; HEPATITIS-C-VIRUS; NF-KAPPA-B; VIRAL PROTEIN-R; RIG-I; MEMBRANE PERMEABILIZATION; ANTIVIRAL RESPONSE; INDUCED APOPTOSIS; REACTIVE OXYGEN; ADAPTER PROTEIN;

D O I：

10.1016/j.smim.2009.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondria have been long recognized for their key role in the modulation of cell death pathways. Thus, it is therefore not surprising that this organelle represents a recurrent target for pathogenic microbes, aiming to manipulate the fate of the infected host cell. More recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling, as illustrated by the identification of MAVS (also known as IPS-1, VISA and Cardif), NLRX1 and STING as mitochondrial proteins. This review discusses the tight interplay between microbial infection, innate immune signaling and mitochondria. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：223 / 232

页数：10

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