Rate acceleration of nucleophilic substitution of 2-chloro-4,6-dimethoxypyrimidine by sulfinate catalysis

被引：44

作者：

Bessard, Y ^{[1
]}

Crettaz, R ^{[1
]}

机构：

[1] Lonza Ltd, Dept Proc Res, CH-3930 Visp, Switzerland

来源：

TETRAHEDRON | 2000年 / 56卷 / 27期

关键词：

aromatic nucleophilic substitution; pyrimidines; sulfinates;

D O I：

10.1016/S0040-4020(00)00390-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of sulfinates greatly enhances the rate of substitution in the reaction of 2-chloro-4,6-dimethoxypyrimidine with alkoxy or aryloxy nucleophiles. Pyrimidinyloxy derivatives as intermediates for potent herbicides have been prepared in good yields from the readily available 2-chloro-4,6-dimethoxypyrimidine. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4739 / 4745

页数：7

共 15 条

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[7] PREPARATION OF HETEROARENECARBONITRILES BY REACTION OF HALOHETEROARENES WITH POTASSIUM CYANIDE CATALYZED BY SODIUM P-TOLUENESULFINATE
MIYASHITA, A
SUZUKI, Y
OHTA, K
HIGASHINO, T
[J]. HETEROCYCLES, 1994, 39 (01) : 345 - 356
[8] MURUGESAN N, 1991, Patent No. 13065
[9] NEWTON TW, Patent No. 9205136
[10] RIECHERS H, Patent No. 19533023

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