Stem cell therapy for chronic skin wounds in the era of personalized medicine: From bench to bedside

被引：59

作者：

Coalson, Elam ^{[1
,2
]}

Bishop, Elliot ^{[2
,3
]}

Liu, Wei ^{[2
,4
]}

Feng, Yixiao ^{[2
,4
]}

Spezia, Mia ^{[2
]}

Liu, Bo ^{[3
,4
]}

Shen, Yi ^{[2
,5
]}

Wu, Di ^{[2
]}

Du, Scott ^{[2
,6
]}

Li, Alexander J. ^{[2
]}

Ye, Zhenyu ^{[2
,7
]}

Zhao, Ling ^{[2
,4
]}

Cao, Daigui ^{[2
,8
]}

Li, Alissa ^{[2
]}

Hagag, Ofir ^{[2
]}

Deng, Alison ^{[2
,6
]}

Liu, Winny ^{[2
,6
]}

Li, Mingyang ^{[2
,6
]}

Haydon, Rex C. ^{[2
]}

Shi, Lewis ^{[2
]}

Athiviraham, Aravind ^{[2
]}

Lee, Michael J. ^{[2
]}

Wolf, Jennifer Moriatis ^{[2
]}

Ameer, Guillermo A. ^{[9
,10
,11
]}

He, Tong-Chuan ^{[2
,11
]}

Reid, Russell R. ^{[3
,11
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[2] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Surg, Sect Plast Surg, Med Ctr, Chicago, IL 60637 USA

[4] Chongqing Med Univ, Coll Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China

[5] Cent S Univ, Xiangya Hosp 2, Dept Orthopaed Surg, Changsha 410011, Hunan, Peoples R China

[6] Illinois Math & Sci Acad, Student Inquiry Res Program, Aurora, IL 60506 USA

[7] Soochow Univ, Affiliated Hosp 2, Dept Gen Surg, Suzhou 215004, Peoples R China

[8] Chongqing Gen Hosp, Dept Orthopaed Surg, Chongqing 400013, Peoples R China

[9] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[10] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60616 USA

[11] Ctr Adv Regenerat Engn, Evanston, IL 60208 USA

来源：

GENES & DISEASES | 2019年 / 6卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Chronic inflammation; Chronic wounds; Growth factors; Personalized medicine; Skin; Stem cells; Wound healing; ENDOTHELIAL PROGENITOR CELLS; FIBROBLAST-GROWTH-FACTOR; BONE-MARROW; MESENCHYMAL STEM; CLINICAL-APPLICATIONS; STROMAL CELLS; VESSEL FORMATION; DIABETIC ULCERS; TISSUE-REPAIR; DOUBLE-BLIND;

D O I：

10.1016/j.gendis.2019.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

With the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient. The most promising potential treatment options rely on stem cell-based therapies. Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function. Clinical approaches involving stem cells could thus be utilized in some cases to improve a body's inhibited healing capacity. We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential. Given the current problems and complications presented by chronic wounds, we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. Copyright (C) 2019, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：342 / 358

页数：17

共 165 条

[1]

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].