The role of DNA repair capacity in susceptibility to lung cancer: A review

被引:70
作者
Wei, QY [1 ]
Spitz, MR [1 ]
机构
[1] Univ Texas, MD Anderson Cancer Ctr, Dept Epidemiol, Houston, TX 77030 USA
关键词
molecular epidemiology; biomarkers; DNA repair capacity; lung cancer; susceptibility; risk assessment;
D O I
10.1023/A:1005852211430
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Human cancer risk assessment has relied largely on animal experiments and use of short-term biological tests based on chemical-DNA interaction. The recent introduction of biomarkers to molecular epidemiologic studies has provided another means of assessing risk for tobacco-related cancer. Several biomarkers for genetic susceptibility to lung cancer have been developed and validated in pilot studies that have demonstrated their association with increased risk of lung cancer. For instance, metabolic enzymes responsible for bioactivation and detoxification of environmental chemicals, carcinogen-induced DNA adducts and chromosomal aberrations, and host DNA repair capacity have been measured in human peripheral lymphocytes. These markers allow estimation of interindividual variation in response to carcinogen exposure and thus assessment of cancer risk. Therefore, epidemiological studies of exposure and of molecular etiology of human carcinogenesis provide a new avenue of cancer risk assessment.
引用
收藏
页码:295 / 307
页数:13
相关论文
共 110 条
  • [1] CHROMOSOME-ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE-HAMSTER CELLS EXPOSED TO VARIOUS CHEMICALS
    ABE, S
    SASAKI, M
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 58 (06) : 1635 - 1641
  • [2] EXCISION REPAIR OF PYRIMIDINE DIMERS INDUCED BY SIMULATED SOLAR-RADIATION IN THE SKIN OF PATIENTS WITH BASAL-CELL CARCINOMA
    ALCALAY, J
    FREEMAN, SE
    GOLDBERG, LH
    WOLF, JE
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (05) : 506 - 509
  • [3] CARCINOGENS ARE MUTAGENS - SIMPLE TEST SYSTEM COMBINING LIVER HOMOGENATES FOR ACTIVATION AND BACTERIA FOR DETECTION
    AMES, BN
    DURSTON, WE
    YAMASAKI, E
    LEE, FD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (08) : 2281 - 2285
  • [4] AMOS CI, 1992, CANCER EPIDEM BIOMAR, V1, P505
  • [5] ATHAS WF, 1991, CANCER RES, V51, P5786
  • [6] DEFICIENT NUCLEOTIDE EXCISION-REPAIR ACTIVITY IN PROTEIN EXTRACTS FROM NORMAL HUMAN-LYMPHOCYTES
    BARRET, JM
    CALSOU, P
    SALLES, B
    [J]. CARCINOGENESIS, 1995, 16 (07) : 1611 - 1616
  • [7] CARCINOGEN METABOLISM IN HUMAN LUNG TISSUES AND THE EFFECT OF TOBACCO SMOKING - RESULTS FROM A CASE CONTROL MULTICENTER STUDY ON LUNG-CANCER PATIENTS
    BARTSCH, H
    PETRUZZELLI, S
    DEFLORA, S
    HIETANEN, E
    CAMUS, AM
    CASTEGNARO, M
    ALEXANDROV, K
    ROJAS, M
    SARACCI, R
    GIUNTINI, C
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1992, 98 : 119 - 124
  • [8] POSSIBLE PROGNOSTIC VALUE OF PULMONARY AH-LOCUS-LINKED ENZYMES IN PATIENTS WITH TOBACCO-RELATED LUNG-CANCER
    BARTSCH, H
    HIETANEN, E
    PETRUZZELLI, S
    GIUNTINI, C
    SARACCI, R
    MUSSI, A
    ANGELETTI, CA
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (02) : 185 - 188
  • [9] MOLECULAR THEMES IN ONCOGENESIS
    BISHOP, JM
    [J]. CELL, 1991, 64 (02) : 235 - 248
  • [10] MOLECULAR MECHANISM OF SLOW ACETYLATION OF DRUGS AND CARCINOGENS IN HUMANS
    BLUM, M
    DEMIERRE, A
    GRANT, DM
    HEIM, M
    MEYER, UA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) : 5237 - 5241