Structural biology - Synchronized division proteins

被引：5

作者：

Burns, R ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Biophys Sect, London SW7 2BZ, England

来源：

NATURE | 1998年 / 391卷 / 6663期

关键词：

D O I：

10.1038/34286

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new connection between eukaryotic mitosis and prokaryotic cell division may have been forged with the structures of two GTPases, which seem to be remarkably similar. The first is the tubulin heterodimer -- a protein that assembles into the microtubules involved in eukaryotic mitosis. And the second, FtsZ, forms a filamentous septum during prokaryotic cell division. Could this just be a coincidence, or does it reflect a common ancestry, indicating conservation of functional properties too?

引用

页码：121 / +

页数：2

共 9 条

[1] Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers [J].

Erickson, HP ;

Taylor, DW ;

Taylor, KA ;

Bramhill, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :519-523

[2] FTSZ, A PROKARYOTIC HOMOLOG OF TUBULIN [J].

ERICKSON, HP .

CELL, 1995, 80 (03) :367-370

[3] STRUCTURAL-CHANGES ACCOMPANYING GTP HYDROLYSIS IN MICROTUBULES - INFORMATION FROM A SLOWLY HYDROLYZABLE ANALOG GUANYLYL-(ALPHA,BETA)-METHYLENE-DIPHOSPHONATE [J].

HYMAN, AA ;

CHRETIEN, D ;

ARNAL, I ;

WADE, RH .

JOURNAL OF CELL BIOLOGY, 1995, 128 (1-2) :117-125

[4] Crystal structure of the bacterial cell-division protein FtsZ [J].

Löwe, J ;

Amos, LA .

NATURE, 1998, 391 (6663) :203-206

[5] OPPOSITE END ASSEMBLY AND DISASSEMBLY OF MICROTUBULES AT STEADY-STATE INVITRO [J].

MARGOLIS, RL ;

WILSON, L .

CELL, 1978, 13 (01) :1-8

[6] DYNAMIC INSTABILITY OF MICROTUBULE GROWTH [J].

MITCHISON, T ;

KIRSCHNER, M .

NATURE, 1984, 312 (5991) :237-242

[7] GUANINE NUCLEOTIDE-DEPENDENT ASSEMBLY OF FTSZ INTO FILAMENTS [J].

MUKHERJEE, A ;

LUTKENHAUS, J .

JOURNAL OF BACTERIOLOGY, 1994, 176 (09) :2754-2758

[8] Structure of the αβtubulin dimer by electron crystallography [J].

Nogales, E ;

Wolf, SG ;

Downing, KH .

NATURE, 1998, 391 (6663) :199-203

[9] A metastable intermediate state of microtubule dynamic instability that differs significantly between plus and minus ends [J].

Tran, PT ;

Walker, RA ;

Salmon, ED .

JOURNAL OF CELL BIOLOGY, 1997, 138 (01) :105-117

← 1 →