Wnt signaling: Moving in a new direction

被引:54
作者
McEwen, DG [1 ]
Peifer, M
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
关键词
D O I
10.1016/S0960-9822(00)00611-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evidence supporting the postulated role of a Wnt ligand in the establishment of planar cell polarity has been elusive, but recent studies show that the movement of epithelial cells during vertebrate gastrulation or Drosophila dorsal closure depends on both a Wnt ligand and the planar cell polarity pathway. (C) 2000 Elsevier Science Ltd. Ail rights reserved.
引用
收藏
页码:R562 / R564
页数:3
相关论文
共 15 条
[1]   Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [J].
Axelrod, JD ;
Miller, JR ;
Shulman, JM ;
Moon, RT ;
Perrimon, N .
GENES & DEVELOPMENT, 1998, 12 (16) :2610-2622
[2]   Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [J].
Boutros, M ;
Paricio, N ;
Strutt, DI ;
Mlodzik, M .
CELL, 1998, 94 (01) :109-118
[3]  
DU SJ, 1995, MOL CELL BIOL, V15, P2625
[4]   Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation [J].
Heisenberg, CP ;
Tada, M ;
Rauch, GJ ;
Saúde, L ;
Concha, ML ;
Geisler, R ;
Stemple, DL ;
Smith, JC ;
Wilson, SW .
NATURE, 2000, 405 (6782) :76-81
[5]  
Heisenberg CP, 1996, DEVELOPMENT, V123, P191
[6]  
MCEWEN DG, 2000, IN PRESS DEVELOPMENT
[7]   Planar polarity in the Drosophila eye:: a multifaceted view of signaling specificity and cross-talk [J].
Mlodzik, M .
EMBO JOURNAL, 1999, 18 (24) :6873-6879
[8]  
MOON RT, 1993, DEVELOPMENT, V119, P97
[9]   Roles of the JNK signaling pathway in Drosophila morphogenesis [J].
Noselli, S ;
Agnès, F .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (04) :466-472
[10]   Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell [J].
Schlesinger, A ;
Shelton, CA ;
Maloof, JN ;
Meneghini, M ;
Bowerman, B .
GENES & DEVELOPMENT, 1999, 13 (15) :2028-2038