The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress

被引：27

作者：

Boysen, Gunnar ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Dept Environm & Occupat Hlth, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Winthrop P Rockefeller Canc Inst, Little Rock, AR 72205 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2017年 / 30卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GAMMA-GLUTAMYL CYCLE; AMINO-ACID-TRANSPORT; CANCER CELL-LINES; TRANSFERASE TRANSPEPTIDASE; TUMOR-CELLS; RESISTANCE; PROLIFERATION; SYSTEM; A549;

D O I：

10.1021/acs.chemrestox.7b00018

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Glutathione (GSH) is the most abundant antioxidant and is believed to maintain redox potential in tissues, cells, and individual compartments. However, GSH concentrations in some tumor cells and tissues have been reported to be as high as 1-10 mM, a concentration that is up to 10,000-fold higher than that of reactive oxygen species. Critical quantitative evaluation of glutathiones proposed functions suggests that glutathione is an amino acid checkpoint. In this role, glutathione contributes to regulating cell proliferation and apoptosis, pending amino acid availability.

引用

页码：1113 / 1116

页数：4

共 27 条

[1]

GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE (GAMMA-GT) AND MAINTENANCE OF THIOL POOLS IN TUMOR-CELLS RESISTANT TO ALKYLATING-AGENTS [J].