Elevated plasma nitrate in patients with crush syndrome caused by the Kobe earthquake

被引：12

作者：

Adachi, J

Morita, S

Yasuda, H

Miwa, A

Ueno, Y

Asano, M

Tatsuno, Y

机构：

[1] Kobe Univ, Sch Med, Dept Legal Med, Chuo Ku, Kobe, Hyogo 650, Japan

[2] Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 650, Japan

来源：

CLINICA CHIMICA ACTA | 1998年 / 269卷 / 02期

关键词：

crush syndrome; nitrate; nitrite; plasma; renal function; earthquake;

D O I：

10.1016/S0009-8981(97)00190-3

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

We investigated the nitric oxide profile in the plasma of ten healthy controls and 29 patients hurt by the Kobe Earthquake. The levels of nitrite (NO2-) and nitrate (NO3-) were measured simultaneously by high-performance liquid chromatography (HPLC) with UV detection using the Griess reaction after the reduction of nitrate to nitrite. Arginine consumed in food or diet-derived nitrite had no effect on the plasma nitrite and nitrate contents of the healthy volunteers. Plasma nitrate was elevated in the crush syndrome patients; whereas neither nitrite nor nitrate was increased in patients with normal renal function. This finding suggests increased nitric oxide synthesis, decreased excretion of nitric oxide in the crush syndrome or both. (C) 1998 Elsevier Science B.V.

引用

页码：137 / 145

页数：9

共 17 条

[1]

APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].