Proteome-Wide Anti-Hepatitis C Virus (HCV) and Anti-HIV Antibody Profiling for Predicting and Monitoring the Response to HCV Therapy in HIV-Coinfected Patients

被引：17

作者：

Burbelo, Peter D. ^{[3
]}

Kovacs, Joseph A. ^{[4
]}

Ching, Kathryn H. ^{[3
]}

Issa, Alexandra T. ^{[3
]}

Iadarola, Michael J. ^{[3
]}

Murphy, Alison A. ^{[1
]}

Schlaak, Joerg F. ^{[2
]}

Masur, Henry ^{[4
]}

Polis, Michael A. ^{[1
]}

Kottilil, Shyam ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Hosp Essen, Essen, Germany

[3] Natl Inst Dent & Craniofacial Res, Neurobiol & Pain Therapeut Sect, Lab Sensory Biol, Bethesda, MD USA

[4] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION; PREVALENCE;

D O I：

10.1086/655780

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We quantified antibody responses to the hepatitis C virus (HCV) proteome that are associated with sustained virologic response (SVR) in human immunodeficiency virus (HIV)/HCV-coinfected patients treated with pegylated interferon and ribavirin. Analysis of pre- and posttreatment samples revealed significant decreases in the combined anti-core, anti-E1, and anti-NS4 HCV antibody titers in those with SVRs but not in those who experienced relapse or who did not respond. Furthermore, anti-HIV p24 antibody titers inversely correlated with treatment response. These results suggest that profiling anti-HCV antibody is useful for monitoring HCV therapy, especially in discriminating between those who experience relapse and those who have SVRs at 48 weeks.

引用

页码：894 / 898

页数：5

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