Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function

被引:533
作者
Tzianabos, AO [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA
关键词
D O I
10.1128/CMR.13.4.523-533.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Polysaccharide immunomodulators were first discovered over 40 years ago. Although very few have been rigorously studied, recent reports have revealed the mechanism of action and structure-function attributes of some of these molecules. Certain polysaccharide immunomodulators have been identified that have profound effects in the regulation of immune responses during the progression of infectious diseases, and studies have begun to define structural aspects of these molecules that govern their function and interaction with cells of the host immune system. These polymers can influence innate and cell-mediated immunity through interactions with T cells, monocytes, macrophages, and polymorphonuclear lymphocytes. The ability to modulate the immune response in an appropriate way can enhance the host's immune response to certain infections. In addition this strategy can be utilized to augment current treatment regimens such as antimicrobial therapy that are becoming less efficacious with the advent of antibiotic resistance. This review focuses on recent studies that illustrate the structural and biologic activities of specific polysaccharide immunomodulators and outlines their potential for clinical use.
引用
收藏
页码:523 / +
页数:13
相关论文
共 81 条
  • [1] PGG-glucan activates NF-kappa B-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line
    Adams, DS
    Pero, SC
    Petro, JB
    Nathans, R
    Mackin, WM
    Wakshull, E
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 62 (06) : 865 - 873
  • [2] Mechanisms of phagocytosis in macrophages
    Aderem, A
    Underhill, DM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 593 - 623
  • [3] Assenmacher M, 1998, EUR J IMMUNOL, V28, P1534, DOI 10.1002/(SICI)1521-4141(199805)28:05<1534::AID-IMMU1534>3.0.CO
  • [4] 2-R
  • [5] RANDOMIZED PHASE I/II TRIAL OF A MACROPHAGE-SPECIFIC IMMUNOMODULATOR (PGG-GLUCAN) IN HIGH-RISK SURGICAL PATIENTS
    BABINEAU, TJ
    MARCELLO, P
    SWAILS, W
    KENLER, A
    BISTRIAN, B
    FORSE, RA
    [J]. ANNALS OF SURGERY, 1994, 220 (05) : 601 - 609
  • [6] BABINEAU TJ, 1994, ARCH SURG-CHICAGO, V129, P1204
  • [7] STRUCTURAL ELUCIDATION OF 2 CAPSULAR POLYSACCHARIDES FROM ONE STRAIN OF BACTEROIDES-FRAGILIS USING HIGH-RESOLUTION NMR-SPECTROSCOPY
    BAUMANN, H
    TZIANABOS, AO
    BRISSON, JR
    KASPER, DL
    JENNINGS, HJ
    [J]. BIOCHEMISTRY, 1992, 31 (16) : 4081 - 4089
  • [8] Presentation of cryptococcal capsular polysaccharide (GXM) on activated antigen-presenting cells inhibits the T-suppressor response and enhances delayed-type hypersensitivity and survival
    Blackstock, R
    Casadevall, A
    [J]. IMMUNOLOGY, 1997, 92 (03) : 334 - 339
  • [9] BLEICHER P, 1995, J BIOTECHNOL HEALTHC, V2, P207
  • [10] BROWDER W, 1987, SURGERY, V102, P206