The nuclear nurture and cytoplasmic nature of localized mRNPs

被引：98

作者：

Giorgi, Corinna ^{[1
]}

Moore, Melissa J. ^{[1
]}

机构：

[1] Brandeis Univ, Howard Hughes Med Inst, Dept Biochem, Waltham, MA 02454 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 02期

关键词：

mRNA localization; exon junction complex; nuclear mRNA processing;

D O I：

10.1016/j.semcdb.2007.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

From yeast to mammals, evidence has emerged in recent years highlighting the essential role played by the nuclear "history" of a messenger RNA in determining its cytoplasmic fate. mRNA localization, translation and stability in the cytoplasm are often pre-destined in the nucleus, and directed by the composition and architecture of nuclear assembled mRNA-protein complexes. In this review we focus on nuclear-acquired RNA-binding proteins and complexes that participate in determining the journey of localized mRNAs. (C) 2007 Published by Elsevier Ltd.

引用

页码：186 / 193

页数：8

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