Apoptosis in yeast

被引：245

作者：

Madeo, F

Herker, E

Wissing, S

Jungwirth, H

Eisenberg, T

Fröhlich, KU

机构：

[1] Karl Franzens Univ Graz, IMB, A-8010 Graz, Austria

[2] Univ Tubingen, Dept Physiol Chem, D-72076 Tubingen, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.mib.2004.10.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Apoptosis is a highly regulated cellular suicide program crucial for metazoan development. However, dysfunction of apoptosis also leads to several diseases. Yeast undergoes apoptosis after application of acetic acid, sugar- or salt-stress, plant antifungal peptides, or hydrogen peroxide. Oxygen radicals seem to be key elements of apoptotic execution, conserved during evolution. Furthermore, several yeast orthologues of central metazoan apoptotic regulators have been identified, such as a caspase and a caspase-regulating serine protease. In addition, physiological occurrence of cell death has been detected during aging and mating in yeast. The finding of apoptosis in yeast, other fungi and parasites is not only of great medical relevance but will also help to understand some of the still unknown molecular mechanisms at the core of apoptotic execution.

引用

收藏

页码：655 / 660

页数：6

相关论文

共 62 条

[1] Oxidative and amphotericin B-mediated cell death in the opportunistic pathogen Aspergillus fumigatus is associated with an apoptotic-like phenotype [J].

Amin, S ;

Mousavi, A ;

Robson, GD .

MICROBIOLOGY-SGM, 2004, 150 :1937-1945

[2] Aspirin commits yeast cells to apoptosis depending on carbon source [J].

Balzan, R ;

Sapienza, K ;

Galea, DR ;

Vassallo, N ;

Frey, H ;

Bannister, WH .

MICROBIOLOGY-SGM, 2004, 150 :109-115

[3] Longevity regulation in Saccharomyces cerevisiae:: Linking metabolism, genome stability, and heterochromatin [J].

Bitterman, KJ ;

Medvedik, O ;

Sinclair, DA .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2003, 67 (03) :376-+

[4] Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast [J].

Blanchard, F ;

Rusiniak, ME ;

Sharma, K ;

Sun, XL ;

Todorov, I ;

Castellano, MM ;

Gutierrez, C ;

Baumann, H ;

Burhans, WC .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (05) :1536-1549

[5] Apoptosis-like yeast cell death in response to DNA damage and replication defects [J].

Burhans, WC ;

Weinberger, M ;

Marchetti, MA ;

Ramachandran, L ;

D'Urso, G ;

Huberman, JA .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 532 (1-2) :227-243

[6] A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae [J].

Butcher, RA ;

Schreiber, SL .

CHEMISTRY & BIOLOGY, 2003, 10 (06) :521-531

[7] The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin [J].

Camougrand, N ;

Grelaud-Coq, A ;

Marza, E ;

Priault, M ;

Bessoule, JJ ;

Manon, S .

MOLECULAR MICROBIOLOGY, 2003, 47 (02) :495-506

[8] Adiposity signals, genetic and body weight regulation in humans [J].

Cancello, R ;

Tounian, A ;

Poitou, C ;

Clément, K .

DIABETES & METABOLISM, 2004, 30 (03) :215-227

[9] Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast [J].

Chae, HJ ;

Ke, N ;

Kim, HR ;

Chen, SR ;

Godzik, A ;

Dickman, M ;

Reed, JC .

GENE, 2003, 323 :101-113

[10] Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae [J].

Chen, SR ;

Dunigan, DD ;

Dickman, MB .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 34 (10) :1315-1325

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