Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia

被引：28

作者：

Amiel, A

Litmanovich, T

Gaber, E

Lishner, M

Avivi, L

Fejgin, MD

机构：

[1] TEL AVIV UNIV,SCH MED,DEPT HUMAN GENET,IL-69978 TEL AVIV,ISRAEL

[2] MEIR HOSP,DEPT MED A,KEFAR SAVA,ISRAEL

来源：

HUMAN GENETICS | 1997年 / 101卷 / 02期

关键词：

D O I：

10.1007/s004390050619

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.

引用

页码：219 / 222

页数：4

共 16 条

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