NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?

被引：17

作者：

Grimm, MC

Pavli, P ^{[1
]}

机构：

[1] Canberra Hosp, Gastroenterol Unit, Woden, ACT 2606, Australia

[2] Univ New S Wales, Dept Med, St George Clin Sch, Sydney, NSW, Australia

来源：

GUT | 2004年 / 53卷 / 11期

关键词：

D O I：

10.1136/gut.2004.043307

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is evidence that CARD15/NOD2 variants in Crohn's disease are associated with diminished mucosal alpha-defensin production, resulting in impaired innate immunity.

引用

页码：1558 / 1560

页数：3

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