Proteases in parasitic diseases

被引:299
作者
McKerrow, James H. [1 ]
Caffrey, Conor
Kelly, Ben
Loke, P'ng
Sajid, Mohammed
机构
[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Sandler Ctr, San Francisco, CA 94143 USA
关键词
parasite; protease inhibitor; invasion; host; immune response;
D O I
10.1146/annurev.pathol.1.110304.100151
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Parasitic diseases represent major global health problems of immense proportion. Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness affect hundreds of millions of people worldwide, cause millions of deaths annually, and present an immense social and economic burden. Recent advances in genomic analysis of several of the major global parasites have revealed key factors involved in the pathogenesis of parasite diseases. Among the major virulence factors identified are parasite-derived proteases. This review focuses on the direct role of proteases in disease pathogenesis. Well-characterized examples of the roles proteases play in pathogenesis include their involvement in invasion of the host by parasite migration through tissue barriers, degradation of hemoglobin and other blood proteins, immune evasion, and activation of inflammation.
引用
收藏
页码:497 / 536
页数:40
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