Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice

被引：30

作者：

Zhang, M ^{[1
]}

Bolfing, MF ^{[1
]}

Knowles, HJ ^{[1
]}

Karnes, H ^{[1
]}

Hackett, BP ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dev Biol Res Unit, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 324卷 / 04期

关键词：

foxj1; left-right asymmetry; node; cilia; nodal; lefty-2; pitx2; heterotaxia;

D O I：

10.1016/j.bbrc.2004.09.207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice with a targeted mutation of the foxjI gene demonstrate either D- or L-looping of the embryonic cardiac tube. Foxj1 is expressed in ventral cells of the embryonic node prior to asymmetric, left-right expression of other genes. Despite an absence of 9 + 2 cilia in fox j1(-/-) mice, 9 + 0 cilia are present in the node of foxjl(-/-) embryos. Infoxj1(-/-) embryos, the patterns of expression of the TGF-beta family member nodal and the homeobox family member pitx2 are randomized. No expression of the TGF-beta family member lefty-2 is observed in any foxj1(-/-) early somite stage embryos. Foxjl thus acts early in left-right axis patterning and regulates asymmetric gene expression. This regulation does not appear to be the result of a direct interaction between Foxjl and the genes examined. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1413 / 1420

页数：8

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