Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1 -: I.: Taxonomy, production, isolation, physico-chemical properties and biological activities

被引：16

作者：

Momose, I ^{[1
]}

Chen, W ^{[1
]}

Kinoshita, N ^{[1
]}

Iinuma, H ^{[1
]}

Hamada, M ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 141, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 01期

关键词：

D O I：

10.7164/antibiotics.51.21

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic designated polyketomycin was isolated from the culture broth of Streptomyces sp. MK277-AF1. It was purified by ethyl acetate extraction, Sephadex LH-20 column chromatography and centrifugal partition chromatography (CPC). It inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Its MICs were less than 0.2 mu g/ml. Polyketomycin exhibited cytotoxic activity against nine tumor cell lines at concentrations of 0.9 similar to 5.2 mu g/ml.

引用

页码：21 / 25

页数：5

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