Average Adherence to Boosted Protease Inhibitor Therapy, rather than the Pattern of Missed Doses, as a Predictor of HIV RNA Replication

被引：68

作者：

Parienti, Jean-Jacques ^{[1
,2
,3
,4
]}

Ragland, Kathleen ^{[8
]}

Lucht, Frederic ^{[5
]}

de la Blanchardiere, Arnaud ^{[2
]}

Dargere, Sylvie ^{[2
]}

Yazdanpanah, Yazdan ^{[6
]}

Dutheil, Jean-Jacques ^{[1
]}

Perre, Philippe ^{[7
]}

Verdon, Renaud ^{[2
]}

Bangsberg, David R. ^{[9
]}

机构：

[1] Cote de Nacre Univ Hosp, Dept Clin Res & Biostat, Caen, France

[2] Cote de Nacre Univ Hosp, Dept Infect Dis, Caen, France

[3] Univ Paris 06, Unite Mixte Rech Sante 707, Paris, France

[4] INSERM, U707, Paris, France

[5] Univ Hosp, Dept Infect Dis, St Etienne, France

[6] Univ Hosp, Dept Infect Dis, Tourcoing, France

[7] Gen Hosp, Dept Infect Dis, La Roche Sur Yon, France

[8] Univ Calif San Francisco, San Francisco Gen Hosp, Div Infect Dis, Epidemiol & Prevent Intervent Ctr, San Francisco, CA USA

[9] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Global Hlth,Harvard Initiat Global Hlth, Boston, MA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 50卷 / 08期

关键词：

PATIENTS RECEIVING LOPINAVIR/RITONAVIR; COMBINATION ANTIRETROVIRAL THERAPY; LESS-THAN; 95-PERCENT; POSITIVE INDIVIDUALS; VIROLOGICAL FAILURE; VIRAL SUPPRESSION; DRUG-RESISTANCE; INTERRUPTIONS; OUTCOMES; REGIMEN;

D O I：

10.1086/651419

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Consecutive missed doses may differentially impact the efficacy of antiretroviral therapy associated with the use of a nonnucleoside reverse-transcriptase inhibitor (NNRTI) and a ritonavir-boosted protease inhibitor (PI). In a cohort of 72 subjects receiving a boosted PI, average adherence to dosage was a better predictor of human immunodeficiency virus (HIV) replication than was the duration or frequency of treatment interruption. In contrast with an NNRTI, consecutive missed doses of a boosted PI did not emerge as a major risk factor for HIV replication.

引用

页码：1192 / 1197

页数：6

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