Human hepatocyte growth factor (HGF) in the aqueous humor

被引：13

作者：

Araki-Sasaki, K

Danjo, S

Kawaguchi, S

Hosohata, J

Tano, Y

机构：

[1] Toyonaka City Hosp, Div Ophthalmol, Toyonaka, Osaka 560, Japan

[2] Kinki Cent Hosp, Div Ophthalmol, Kinki, Japan

[3] Osaka Univ, Sch Med, Dept Ophthalmol, Osaka, Japan

来源：

JAPANESE JOURNAL OF OPHTHALMOLOGY | 1997年 / 41卷 / 06期

关键词：

aqueous humor; c-MET cell density; corneal endothelial cell; hepatocyte growth factor;

D O I：

10.1016/S0021-5155(97)00081-6

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Using an enzyme-linked immunosorbent assay, we measured the concentration of hepatocyte growth factor (HGF) in human aqueous humor and serum from 36 eyes of 33 patients and analyzed the relationship between HGF and several parameters of corneal endothelial cells. Aqueous HGF concentrations ranged from 0.020-0.194 ng/mL (average: 0.101 +/- 0.034 ng/mL) and was correlated positively with corneal endothelial cell density (r = 0.343, P = 0.01). The aqueous HGF level did not correlate with other corneal endothelial cell parameters or the serum HGF level. The HGF receptor, c-Met, was found in the corneal endothelial cell membranes. This study suggests that the aqueous humor HGF is a factor which maintains an integrity of corneal endothelial cells. (C) 1997 Japanese Ophthalmological Society.

引用

页码：409 / 413

页数：5

共 32 条

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