Absence of a functional defect in CD+ T cells during primary murine gammaherpesvirus-68 infection of I-A b-/- mice

被引：22

作者：

Belz, GT ^{[1
]}

Liu, HY ^{[1
]}

Andreansky, S ^{[1
]}

Doherty, PC ^{[1
]}

Stevenson, PG ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1099/vir.0.18821-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine gammaherpesvirus-68 kills I-A(b-/-) mice despite the presence of virus-specific CD8(+) cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab(-/-) mice and I-Ab(+/+) controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4(+) T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

引用

页码：337 / 341

页数：5

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