Effects of added dimethylsulfoxide on pKa values of uncharged organic acids and pH values of aqueous buffers.

被引：24

作者：

Mukerjee, P

Ostrow, JD

机构：

[1] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA

[2] Univ Amsterdam, Acad Med Ctr, Gastrointestinal Liver Dept, NL-1105 AZ Amsterdam, Netherlands

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 5-6期

关键词：

D O I：

10.1016/S0040-4039(97)10537-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recent studies of pKa values of carboxylic acids in (CD3)(2)SO-aq. buffer mixtures, using (COOH)-C-13-NMR, conflict with our new data and other reports, which show that the pK(a) of uncharged carboxylic acids and pH values of anionic buffers increase dramatically with increasing vol% DMSO. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：423 / 426

页数：4

共 21 条

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